Los Angeles Chargers at San Francisco 49ers: Sport predictions, picks, odds
Justin Herbert’s Los Angeles Chargers (5-3) have the better record, but it’s Jimmy Garoppolo and the San Francisco 49ers (4-4) who are favored at home by a touchdown in this Week 10 matchup.
The 49ers have been rolling on offense since adding Christian McCaffrey to an already talented unit featuring Deebo Samuel and George Kittle. Meanwhile, the Chargers are banged up on both sides of the field and have been scrapping to get wins. Which team comes out on top? The game is set to kick off Sunday at 8:20 pm ET from Levi’s Stadium.
Here’s a look at the betting details and USA TODAY’s NFL staff picks for the Chargers vs. 49ers Week 10 game:
Chargers at 49ers odds, moneyline and over/under
Follow every game: Live NFL Scores
NFL BOLD PREDICTIONS:NFL bold predictions for the second half: When will Eagles lose? Bears… in the playoffs?
WEEK 9 NFL COACHING GRADE:Bengals, Jets score high marks after big wins; Colts, Raiders fail
NFL WEEK 9 WINNERS AND LOSERS:Tom Brady saves Buccaneers’ season, Packers hit rock bottom
Lorenzo Reyes: 49ers 30, Chargers 20
The Chargers escaped Sunday in a game they should’ve lost. Their offense is frustratingly inefficient at times, and coordinator Joe Lombardi’s job is in peril. San Francisco is at home and off the bye.
Safid Deen: 49ers 27, Chargers 20
The injured Chargers are finding a way to stay alive this season, but it won’t find success against a revamped 49ers team pushing toward the Super Bowl this season. It’ll be fought hard, but San Francisco wins.
Lance Pugmire: 49ers 30, Chargers 17
Plagued by injuries and dubious coaching, Los Angeles falls prey to the sudden NFC power on Sunday night. At least the Chargers don’t have to feel the sting of playing a road game at home given what the 49ers’ throng annually do to the Rams.
32 THINGS WE LEARNED:Bills may regret last week; Packers, Rams done?
NEW BUCKETS:The NFL has returned alternate helmets in 2022: Ranking all 13 from best to worst
IN DEPTH:The NFL coaches project
NFL salaries: These are the highest-paid NFL players
Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See applicable operator site for its terms and conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER. Must be 21 or older to gamble.
