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San Francisco 49ers at Los Angeles Rams odds, picks and prediction

the San Francisco 49ers (9-7) can secure their place in the postseason with a win on Sunday if they have the Los Angeles Rams (12-4) in the SoFi stadium. This NFC West matchup kicks off at 4:25 p.m. ET. Below we look at those 49ers vs. Rams odds and lines, and make our best NFL tips, predictions and bets.

The 49ers have won 7-3 in their last 10 games since the start of the season 2-4 and turned things around completely to get in position to make the playoffs. Her most recent win was a 23-7 win over the Houston Texans in Week 17, a game that rookie QB played Trey Lance started instead of the injured QB Jimmy Garoppolo.

San Francisco has played well in the past few weeks, scoring at least 23 points in seven of their last eight games, and facing a team they have beaten five times in a row.

The Rams have won five straight games since losing three straight games in November. They beat players like the Arizona Cardinals, Minnesota Vikings, and Baltimore Ravens in this section. The Rams still haven’t won NFC West with Arizona just one game down on the table. However, the Rams will be crowned division champions on Sunday with a victory.

49ers at Rams odds, spreads and lines

Tipico Sportsbook odds; Access USA TODAY Sports Results and Sports Betting Odds Hub for a complete listing. The rows were last updated at 9:02 a.m. ET.

  • Money line: 49ers +155 (bet $ 100 to win $ 155) | Rams -190 (bet $ 190 to win $ 100)
  • Against Spread (ATS): 49er +3.5 (-112) | Aries -3.5 (-108)
  • Over / Under (O / U): 44.5 (O: -110 | U: -110)

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49ers in Rams key breaches

49er

  • LT Trent Williams (Elbow) questionable
  • QB Jimmy Garoppolo (Thumb) questionable
  • CB K’Waun Williams (COVID-19) questionable
  • LB Azeez Al-Shaair (Knee) questionable
  • LB Dre Greenlaw (Groin) questionable
  • S. Jaquiski Tartt (Shoulder) questionable

Aries

Let’s make that interesting

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49ers at Rams odds, lines, predictions and tips

forecast

Rams 27, 49er 21

Money line

The 49ers own the Rams lately. They’ve won against Los Angeles five times in a row since 2019, including a 31:10 win in Week 10 of that season. However, the Rams are rolling right now and have managed to win five in a row despite QB Matthew StaffordSales problems.

I like RAMS (-190) to win directly at home with the division title.

Against the spread

The 49ers are 7-3 ATS against the Rams in their last 10 games. They have had this rivalry since Sean McVay took over as head coach for the Rams. However, the 49ers have huge injury concerns while Los Angeles is as healthy as it is all year.

Take the RAM -3.5 (-108) at almost the same money to cover the spread.

Over under

The over / under is divided 5-5 in the last 10 games between these teams. The Under is also this season in the last 10 games for both the Rams and the 49ers 6-4.

With San Francisco’s secondary key figures potentially missing and the Rams offensive moving the ball well – aside from Stafford’s turnovers – I see this game going OVER 44.5 (-110).

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